To jam and learn 2Pac - Pain chords, your primary focus should be mastering these chords sequence: Eb, Abm, Dbm, A, Abm, Eb, A, Dbm and Eb. A strategic approach would be to train at 41 BPM initially, and then accelerate to the song's tempo of 84. Align the capo with your vocal depth and chord choice, bearing in mind the song's original key: F Major.